MICHIGAN INNOVATIVE DIAGNOSTICS

The Adult Cardiovascular Risk Profile is a consolidated assessment of the metabolic, lipoprotein, inflammatory, and hematologic factors that contribute to atherosclerotic cardiovascular disease. Beyond the standard lipid panel, the profile quantifies atherogenic particle burden through Apolipoprotein B and the ApoB/ApoA1 ratio, captures the independent and largely heritable risk conferred by Lipoprotein (a), and measures homocysteine and high-sensitivity C-reactive protein as markers of vascular injury and low-grade systemic inflammation. A comprehensive metabolic panel, complete blood count with automated differential, ESR, CK, and LDH establish concurrent renal, hepatic, hematologic, and tissue-injury status.

​

Intended for adults undergoing baseline or periodic cardiovascular risk stratification, including patients with a family history of premature coronary disease, borderline or discordant conventional lipid results, metabolic syndrome, or established risk factors under active management. Results are intended to supplement clinical risk assessment tools such as the ASCVD Pooled Cohort Equations and should be interpreted alongside the patient's history, examination, and medication profile.

​

This profile is not a diagnostic test for acute coronary syndrome and is not appropriate for the evaluation of acute chest pain.

​

LIS PROFILE CODE: (MID) Adult Cardiovascular Risk Profile

​

INDIVIDUAL LIS/PANEL TEST CODES INCLUDED WITHIN PROFILE: (MID) Comprehensive Metabolic Panel (CMP), (MID) Complete Blood Count with Automated Differential (CBCWD), CK, LDH, (MID) Lipid Panel (LP), (MID) Apolipoprotein B / Apolipoprotein A1 Ratio, LIPOA, HOMO, CRPWR, (REF) HSCRP, ESR

​

CPT CODE: 80053 (CMP) + 85025 (CBCWD) + 82550 (CK) + LDH (83615) + 80061 (LP) + 82172 x 2 (APO B / APO A1 Ratio) + 83695 (LIPOA) + 82746 (HOMO) + 86140 (CRP) + 86141 (HSCRP) + 85652 (ESR)

​

NOTE: The ApoB/ApoA1 ratio is a calculated result and is not separately billable. This is a MID-defined profile, not an AMA-recognized panel; components are billed individually and each must be supported by documented medical necessity. Several payers restrict coverage of HSCRP, Lp(a), homocysteine, and apolipoprotein testing.

​

ALIASES: Cardiac Risk Profile, CV Risk Panel, Advanced Lipid & Inflammation Profile, ASCVD Risk Assessment

​

METHODOLOGIES: Spectrophotometry, Ion-Selective Electrode (ISE), Hydrodynamic Impedance, Laser-Based Flow Cytometry, Sodium Lauryl Sulfate (SLS) Hemoglobin, Automated Westergren (Excyte Mini)

​

PATIENT PREPARATION: 9 - 12 hour fast (water permitted) required for Lipid Panel and CMP glucose. Avoid strenuous physical activity for 24 - 48 hours prior to collection; exertion, IM injections, and recent trauma elevate CK. Avoid alcohol for 24 hours prior. Patient should be seated at rest for at least 5 minutes prior to venipuncture.

​

SPECIMEN:

​​

- Type: Serum & Whole Blood

​

- Container: 2 Gold Top (SST) Vacutainers & 1 Lavender Top (K2/K3 EDTA) Vacutainer

​

- Minimum Volume Required: 2 mL for each container

​

- Order of Draw: Gold Top (SST) before Lavender Top (K2/K3 EDTA) per CLSI GP41.

​

- Storage/Handling:

 

Gold Top (SST) Vacutainer - Allow 30 minutes for blood to clot, then centrifuge specimen at 3500 RPM for 10 minutes. Maintain specimen at room temperature or in the refrigerator until testing can be performed.

​

Lavender Top (K2/K3 EDTA) Vacutainer - Gently invert specimen 8 - 10 times immediately following blood collection to prevent clotting. Maintain specimen at room temperature or in the refrigerator until testing can be performed.

​

- Stability:   

 

Room Temperature (20-25 °C): 2 hours

Refrigerated (2-8 °C): 2 days (please note however that cellular degeneration can occur as soon as 24 hours post-collection)

Frozen (-20 °C or colder): Not Accepted

​

- Turnaround Time: 24 - 48 hours from receipt.

​

Special Instructions: Specimens meeting predefined criteria (e.g., flagged morphologic abnormalities, significant differential shifts, or critical count thresholds) will automatically reflex to a peripheral blood smear review by a medical laboratory scientist at no additional charge.

 

Depending on the findings identified on smear review, the specimen may be further escalated to pathologist for final interpretation, and any additional testing will be added to the original order.

​

To minimize increases in homocysteine concentration from synthesis by RBCs, place all specimens (serum and plasma) on ice after collection and prior to processing.

​

CK and LDH are markers of tissue injury rather than cardiovascular risk stratification. Elevated results within this profile should be interpreted in the context of recent exertion, trauma, hemolysis, or muscle disease.

 

Lipoprotein (a) is largely genetically determined and is generally measured once in a lifetime unless a therapeutic intervention targeting Lp(a) is initiated.

​

REJECTION REASONS: Clotted Specimen, QNS, Gross Hemolysis, Gross Lipemia, Contamination, Stability Violation, Expired Container, Incorrect Container

​

REFERENCE RANGES:​

​

Please refer to individual test/panel directory pages for reference ranges for each test/panel included.

​

​