MICHIGAN INNOVATIVE DIAGNOSTICS

Broad syndromic real-time PCR panel that detects 36 targets: respiratory viral pathogens, EBV, an extensive menu of bacteria associated with respiratory tract infection and pneumonia, and the mecA methicillin/oxacillin resistance marker, all from a single nasopharyngeal specimen.

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LIS PANEL CODE: (MID) Respiratory Plus PCR (RPP) Panel

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INDIVIDUAL LIS TEST CODES INCLUDED WITHIN PANEL: SARS-CoV-2, Influenza A, Influenza B, RSV, Adenovirus, Bocavirus, HCoV 229E, HCoV HKU1, HCoV NL63, HCoV OC43, EBV (mononucleosis), Enterovirus, HMPV A, HMPV B, PIV 1, PIV 2, PIV 3, PIV 4, Rhinovirus, Acinetobacter baumannii, Bordetella pertussis, Chlamydophila pneumoniae, Enterobacter cloacae, Haemophilus influenzae, Klebsiella aerogenes., Klebsiella pneumoniae, Legionella pneumophila, Moraxella catarrhalis, Mycoplasma pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumonia, Strep. pyogenes (Group A), Methicillin/Oxacillin (mecA)

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CPT CODE: 87633 (Viral targets) + 87640 (S. aureus) + 87641 (S. aureus, methicillin-resistant) + 87486 (Chlamydophila/Chlamydia pneumoniae) + 87581 (Mycoplasma pneumoniae) + 87798 (infectious agent, not otherwise specified, amplified probe technique) x remaining organisms

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ALIASES: Expanded Respiratory Pathogen Panel, PCR

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METHODOLOGIES: Real-Time Reverse Transcription PCR (RT-PCR), Multiplex Amplified Probe Technique

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Laboratory Developed Test (LDT): Performance characteristics determined by Michigan Innovative Diagnostics. This test has not been cleared or approved by the FDA.

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SPECIMEN:

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- Type: Nasopharyngeal Swab

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- Container: E-Swab (Sterile Swab with Liquid Amies Transport Medium)

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- Minimum Volume Required: N/A (Single Swab)

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- Storage/Handling: Store swab refrigerated (2-8°C) and test within 7 days of collection.

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- Stability:   

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Room Temperature (20-25 °C): Not Accepted 

Refrigerated (2-8 °C): 7 days

Frozen (-20 °C or colder): Not Accepted

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- Turnaround Time: 24 - 48 hours from receipt.

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Special Instructions: Due to genetic similarity, this assay does not reliably differentiate Rhinovirus from Enterovirus, or Coronavirus OC43 from HKU1. If four or more organisms are detected on a single specimen, retesting is highly recommended to confirm the polymicrobial result. Any positive result for SARS-CoV-2, Influenza, RSV, or B. pertussis is treated as a critical value and will be called to the ordering provider.

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REJECTION REASONS: Dry Swab, Leaking/Insufficient Transport Media, Stability Violation, Unlabeled/Mislabeled Specimen, Expired Container, Incorrect Container

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EXPECTED FINDINGS:​​

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VIRAL PATHOGENS

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SARS-CoV-2: Not Detected

Influenza A: Not Detected

Influenza B: Not Detected

RSV: Not Detected

Adenovirus: Not Detected

Bocavirus: Not Detected

HCoV 229E: Not Detected

HCoV HKU1: Not Detected

HCoV NL63: Not Detected

HCoV OC43: Not Detected

EBV (mononucleosis): Not Detected

Enterovirus: Not Detected

HMPV A: Not Detected

HMPV B: Not Detected

PIV 1: Not Detected

PIV 2: Not Detected

PIV 3: Not Detected

PIV 4: Not Detected

Rhinovirus: Not Detected

 

BACTERIAL PATHOGENS

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Acinetobacter baumannii: Not Detected

Bordetella pertussis: Not Detected

Chlamydophila pneumoniae: Not Detected

Enterobacter cloacae: Not Detected

Haemophilus influenzae: Not Detected

Klebsiella aerogenes: Not Detected

Klebsiella pneumoniae: Not Detected

Legionella pneumophila: Not Detected

Moraxella catarrhalis: Not Detected

Mycoplasma pneumoniae: Not Detected

Proteus mirabilis: Not Detected

Pseudomonas aeruginosa: Not Detected

Staphylococcus aureus: Not Detected

Staphylococcus epidermidis: Not Detected

Streptococcus pneumonia: Not Detected

Strep. pyogenes (Group A): Not Detected

 

GENETIC RESISTANCE MARKERS

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Methicillin/Oxacillin (mecA): Not Detected

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Panic Threshold(s): Detected for SARS-CoV-2, Influenza A, Influenza B, RSV, or Bordetella pertussis.

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